| First Author | Lynes MD | Year | 2022 |
| Journal | Stem Cells | Volume | 40 |
| Issue | 1 | Pages | 102-111 |
| PubMed ID | 35511869 | Mgi Jnum | J:362246 |
| Mgi Id | MGI:8157893 | Doi | 10.1093/stmcls/sxab005 |
| Citation | Lynes MD, et al. (2022) Telomerase Reverse Transcriptase Expression Marks a Population of Rare Adipose Tissue Stem Cells. Stem Cells 40(1):102-111 |
| abstractText | In adult tissues such as adipose tissue, post-mitotic cells like adipocytes can be replaced by differentiation of a population of tissue-resident stem cells. Expression of mouse telomerase reverse transcriptase (mTert) is a hallmark of stem cell populations, and previous efforts to identify tissue-resident adult stem cells by measuring mTert expression have increased our understanding of stem cell biology significantly. Here, we used a doxycycline-inducible mouse model to perform longitudinal, live-animal lineage-tracing of mTert-expressing cells for more than 1 year. We identified a rare (<2%) population of stem cells in different fat depots that express putative preadipocyte markers. The adipose-derived mTert-positive cells are capable of self-renewal and possess adipogenic potential. Finally, we demonstrate that high-fat diet (HFD) can initiate differentiation of these cells in vivo. These data identify a population of adipose stem cells that contribute to the depot-specific response to HFD. |
