| First Author | Molodtsov AK | Year | 2021 |
| Journal | Immunity | Volume | 54 |
| Issue | 9 | Pages | 2117-2132.e7 |
| PubMed ID | 34525340 | Mgi Jnum | J:370605 |
| Mgi Id | MGI:6856564 | Doi | 10.1016/j.immuni.2021.08.019 |
| Citation | Molodtsov AK, et al. (2021) Resident memory CD8(+) T cells in regional lymph nodes mediate immunity to metastatic melanoma. Immunity 54(9):2117-2132.e7 |
| abstractText | The nature of the anti-tumor immune response changes as primary tumors progress and metastasize. We investigated the role of resident memory (Trm) and circulating memory (Tcirm) cells in anti-tumor responses at metastatic locations using a mouse model of melanoma-associated vitiligo. We found that the transcriptional characteristics of tumor-specific CD8(+) T cells were defined by the tissue of occupancy. Parabiosis revealed that tumor-specific Trm and Tcirm compartments persisted throughout visceral organs, but Trm cells dominated lymph nodes (LNs). Single-cell RNA-sequencing profiles of Trm cells in LN and skin were distinct, and T cell clonotypes that occupied both tissues were overwhelmingly maintained as Trm in LNs. Whereas Tcirm cells prevented melanoma growth in the lungs, Trm afforded long-lived protection against melanoma seeding in LNs. Expanded Trm populations were also present in melanoma-involved LNs from patients, and their transcriptional signature predicted better survival. Thus, tumor-specific Trm cells persist in LNs, restricting metastatic cancer. |
