| First Author | Jeong JY | Year | 2025 |
| Journal | NPJ Parkinsons Dis | Volume | 11 |
| Issue | 1 | Pages | 228 |
| PubMed ID | 40759658 | Mgi Jnum | J:389952 |
| Mgi Id | MGI:8369509 | Doi | 10.1038/s41531-025-01091-z |
| Citation | Jeong JY, et al. (2025) Elevated plasma levels of alpha-synuclein are dispensable for Parkinson's disease pathology. NPJ Parkinsons Dis 11(1):228 |
| abstractText | Although alpha-synuclein levels are elevated in the blood plasma of Parkinson's disease (PD) patients, it remains unclear whether blood-derived alpha-synuclein directly contributes to PD. To investigate this, we developed a novel mouse model in which human alpha-synuclein levels are increased in the blood. Despite a significant increase in alpha-synuclein in the blood, no noticeable behavioral abnormalities were observed in aged mice. Additionally, we did not observe plasma alpha-synuclein aggregation in the blood or entry of human alpha-synuclein into the brain. These results suggest that elevated blood levels of alpha-synuclein may not be sufficient to induce PD progression. |
