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Publication : An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes.

First Author  Furlanis E Year  2025
Journal  Neuron Volume  113
Issue  10 Pages  1525-1547.e15
PubMed ID  40403705 Mgi Jnum  J:367662
Mgi Id  MGI:8210793 Doi  10.1016/j.neuron.2025.05.002
Citation  Furlanis E, et al. (2025) An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes. Neuron 113(10):1525-1547.e15
abstractText  In recent years, we and others have identified a number of enhancers that, when incorporated into rAAV vectors, can restrict the transgene expression to particular neuronal populations. Yet, viral tools to access and manipulate specific neuronal subtypes are still limited. Here, we performed systematic analysis of single-cell genomic data to identify enhancer candidates for each of the telencephalic interneuron subtypes. We established a set of enhancer-AAV tools that are highly specific for distinct cortical interneuron populations and striatal cholinergic interneurons. These enhancers, when used in the context of different effectors, can target (fluorescent proteins), observe activity (GCaMP), and manipulate (opto-genetics) specific neuronal subtypes. We also validated our enhancer-AAV tools across species. Thus, we provide the field with a powerful set of tools to study neural circuits and functions and to develop precise and targeted therapy.
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