| First Author | Nakano Y | Year | 2026 |
| Journal | iScience | Volume | 29 |
| Issue | 9 | Pages | 117341 |
| PubMed ID | 42707066 | Mgi Jnum | J:391705 |
| Mgi Id | MGI:8409746 | Doi | 10.1016/j.isci.2026.117341 |
| Citation | Nakano Y, et al. (2026) CASZ1 regulates the maturation of outer hair cells and is required for hearing in mice. iScience 29(9):117341 |
| abstractText | The transcription factor ATOH1 is a master regulator of mechanosensory hair-cell (HC) development in the ear. Here, we report that its target gene Casz1 regulates the maturation of outer HCs (OHCs). Genetic deletion of Casz1 during (but not after) cochlear development in the mouse caused: hearing loss; disorganization of mechanosensory stereocilia bundles in OHCs; reduced F-actin density in OHC cuticular plates; progressive OHC loss; and mild morphological alterations in inner HCs. This deletion also altered gene expression, delaying downregulation of genes expressed in immature OHCs, including the actin regulator-encoding gene Coro2a, and accelerating upregulation of genes expressed in mature OHCs. Deleting Coro2a in Casz1 mutant mice restored F-actin density in cuticular plates but increased stereocilia bundle disorganization and hearing thresholds, revealing that CORO2A provides an overall beneficial effect. Our data indicate that CASZ1 regulates transcriptional and morphological maturation of OHCs, and that CASZ1 in maturing HCs is necessary for hearing. |
