| First Author | Shiri Z | Year | 2015 |
| Journal | Ann Neurol | Volume | 77 |
| Issue | 3 | Pages | 541-6 |
| PubMed ID | 25546300 | Mgi Jnum | J:365858 |
| Mgi Id | MGI:8188306 | Doi | 10.1002/ana.24342 |
| Citation | Shiri Z, et al. (2015) Interneuron activity leads to initiation of low-voltage fast-onset seizures. Ann Neurol 77(3):541-6 |
| abstractText | Seizures in temporal lobe epilepsy can be classified as hypersynchronous and low-voltage fast according to their onset patterns. Experimental evidence suggests that low-voltage fast-onset seizures mainly result from the synchronous activity of gamma-aminobutyric acid-releasing cells. In this study, we tested this hypothesis using the optogenetic control of parvalbumin-positive interneurons in the entorhinal cortex, in the in vitro 4-aminopyridine model. We found that both spontaneous and optogenetically induced seizures had similar low-voltage fast-onset patterns. In addition, both types of seizures presented with higher ripple than fast ripple rates. Our data demonstrate the involvement of interneuronal networks in the initiation of low-voltage fast-onset seizures. |
