| First Author | Keller CH | Year | 2018 |
| Journal | J Neurophysiol | Volume | 120 |
| Issue | 1 | Pages | 105-114 |
| PubMed ID | 29589814 | Mgi Jnum | J:365854 |
| Mgi Id | MGI:8188302 | Doi | 10.1152/jn.00911.2017 |
| Citation | Keller CH, et al. (2018) Gap encoding by parvalbumin-expressing interneurons in auditory cortex. J Neurophysiol 120(1):105-114 |
| abstractText | Synaptic inhibition shapes the temporal processing of sounds in auditory cortex, but the contribution of specific inhibitory cell types to temporal processing remains unclear. We recorded from parvalbumin-expressing (PV+) interneurons in auditory cortex to determine how they encode gaps in noise, a model of temporal processing more generally. We found that PV+ cells had stronger and more prevalent on-responses, off-responses, and postresponse suppression compared with presumed pyramidal cells. We summarize this pattern of differences as "deeper modulation" of gap responses in PV+ cells. Response latencies were also markedly faster for PV+ cells. We found a similar pattern of deeper modulation and faster latencies for responses to white noise bursts, suggesting that these are general properties of on- and off-responses in PV+ cells rather than specific features of gap encoding. These findings are consistent with a role for PV+ cells in providing dynamic gain control by pooling local activity. NEW & NOTEWORTHY We found that parvalbumin-expressing (PV+) interneurons in auditory cortex showed more deeply modulated responses to both gaps in noise and bursts of noise, suggesting that they are optimized for the rapid detection of stimulus transients. |
