| First Author | Liu MZ | Year | 2019 |
| Journal | Proc Natl Acad Sci U S A | Volume | 116 |
| Issue | 52 | Pages | 27011-27017 |
| PubMed ID | 31806757 | Mgi Jnum | J:308660 |
| Mgi Id | MGI:6740354 | Doi | 10.1073/pnas.1905658116 |
| Citation | Liu MZ, et al. (2019) Synaptic control of spinal GRPR(+) neurons by local and long-range inhibitory inputs. Proc Natl Acad Sci U S A |
| abstractText | Spinal gastrin-releasing peptide receptor-expressing (GRPR(+)) neurons play an essential role in itch signal processing. However, the circuit mechanisms underlying the modulation of spinal GRPR(+) neurons by direct local and long-range inhibitory inputs remain elusive. Using viral tracing and electrophysiological approaches, we dissected the neural circuits underlying the inhibitory control of spinal GRPR(+) neurons. We found that spinal galanin(+) GABAergic neurons form inhibitory synapses with GRPR(+) neurons in the spinal cord and play an important role in gating the GRPR(+) neuron-dependent itch signaling pathway. Spinal GRPR(+) neurons also receive inhibitory inputs from local neurons expressing neuronal nitric oxide synthase (nNOS). Moreover, spinal GRPR(+) neurons are gated by strong inhibitory inputs from the rostral ventromedial medulla. Thus, both local and long-range inhibitory inputs could play important roles in gating itch processing in the spinal cord by directly modulating the activity of spinal GRPR(+) neurons. |
