| First Author | Onorato I | Year | 2025 |
| Journal | Cell Rep | Volume | 44 |
| Issue | 3 | Pages | 115385 |
| PubMed ID | 40048428 | Mgi Jnum | J:364946 |
| Mgi Id | MGI:8174304 | Doi | 10.1016/j.celrep.2025.115385 |
| Citation | Onorato I, et al. (2025) Distinct roles of PV and Sst interneurons in visually induced gamma oscillations. Cell Rep 44(3):115385 |
| abstractText | Gamma-frequency oscillations are a hallmark of active information processing and are generated by interactions between excitatory and inhibitory neurons. To examine the contribution of distinct inhibitory interneurons to visually induced gamma oscillations, we recorded from optogenetically identified PV+ (parvalbumin) and Sst+ (somatostatin) interneurons in mouse primary visual cortex (V1). PV and Sst inhibitory interneurons exhibited distinct correlations to gamma oscillations. PV cells were strongly phase locked, while Sst cells were weakly phase locked, except for narrow-waveform Sst cells. PV cells fired at a substantially earlier phase in the gamma cycle ( approximately 6 ms) than Sst cells. PV cells fired shortly after the onset of tightly synchronized burst events in excitatory cells, while Sst interneurons fired after subsequent burst spikes or single spikes. These findings indicate a main role of PV interneurons in synchronizing network activity and suggest that PV and Sst interneurons control the excitability of somatic and dendritic neural compartments with precise time delays coordinated by gamma oscillations. |
