| Primary Identifier | MGI:3613486 | Allele Type | Targeted |
| Attribute String | Conditional ready, No functional change | Gene | Dnmt1 |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| description | Mouse embryo fibroblasts derived from chimeric mice made with Dnmt1tm2Jae/Dnmt1tm4Jae ES cells in which imprinting had been eliminated (J:104860) display a significantly faster growth rate with nearly half (47%) of cells in the G2 or M phase of the cell cycle. These MEF cells become spontaneously immortalized. The chimeric mice experience widespread tumorigenesis. |
| molecularNote | A stop cassette flanked by two Frt sites was inserted between the fourth and fifth exons. Upon Flp expression, the allele resumes function as the stop cassette is removed. |
