| First Author | Oberto VJ | Year | 2023 |
| Journal | Front Cell Neurosci | Volume | 17 |
| Pages | 1131313 | PubMed ID | 37426551 |
| Mgi Jnum | J:365540 | Mgi Id | MGI:7507902 |
| Doi | 10.3389/fncel.2023.1131313 | Citation | Oberto VJ, et al. (2023) Rhythmic oscillations in the midbrain dopaminergic nuclei in mice. Front Cell Neurosci 17:1131313 |
| abstractText | INTRODUCTION: Dopamine release in the forebrain by midbrain ventral tegmental nucleus (VTA) and substantia nigra pars compacta (SNc) neurons is implicated in reward processing, goal-directed learning, and decision-making. Rhythmic oscillations of neural excitability underlie coordination of network processing, and have been reported in these dopaminergic nuclei at several frequency bands. This paper provides a comparative characterization of several frequencies of oscillations of local field potential and single unit activity, highlighting some behavioral correlates. METHODS: We recorded from optogenetically identified dopaminergic sites in four mice training in operant olfactory and visual discrimination tasks. RESULTS: Rayleigh and Pairwise Phase Consistency (PPC) analyses revealed some VTA/SNc neurons phase-locked to each frequency range, with fast spiking interneurons (FSIs) prevalent at 1-2.5 Hz (slow) and 4 Hz bands, and dopaminergic neurons predominant in the theta band. More FSIs than dopaminergic neurons were phase-locked in the slow and 4 Hz bands during many task events. The highest incidence of phase-locking in neurons was in the slow and 4 Hz bands, and occurred during the delay between the operant choice and trial outcome (reward or punishment) signals. DISCUSSION: These data provide a basis for further examination of rhythmic coordination of activity of dopaminergic nuclei with other brain structures, and its impact for adaptive behavior. |
