Other
14 Authors
- Fu X,
- Wang Z,
- Maricelli J,
- Zhu MJ,
- Wang B,
- Yang Q,
- de Avila JM,
- Zou T,
- Nie W,
- Liang X,
- Zhao J,
- Gao P,
- Du M,
- Rodgers BD
| First Author | Wang B | Year | 2017 |
| Journal | EBioMedicine | Volume | 18 |
| Pages | 288-299 | PubMed ID | 28408241 |
| Mgi Jnum | J:374449 | Mgi Id | MGI:8259450 |
| Doi | 10.1016/j.ebiom.2017.03.041 | Citation | Wang B, et al. (2017) Maternal Retinoids Increase PDGFRalpha(+) Progenitor Population and Beige Adipogenesis in Progeny by Stimulating Vascular Development. EBioMedicine 18:288-299 |
| abstractText | Maternal vitamin A intake varies but its impact on offspring metabolic health is unknown. Here we found that maternal vitamin A or retinoic acid (RA) administration expanded PDGFRalpha(+) adipose progenitor population in progeny, accompanied by increased blood vessel density and enhanced brown-like (beige) phenotype in adipose tissue, protecting offspring from obesity. Blockage of retinoic acid signaling by either BMS493 or negative RA receptor (RARalphaDN) over-expression abolished the increase in blood vessel density, adipose progenitor population, and beige adipogenesis stimulated by RA. Furthermore, RA-induced beige adipogenesis was blocked following vascular endothelial growth factor receptor (VEGFR) 2 knock out in PDGFRalpha(+) cells, suggesting its mediatory role. Our data reveal an intrinsic link between maternal retinoid level and offspring health via promoting beige adipogenesis. Thus, enhancing maternal retinoids is an amiable therapeutic strategy to prevent obesity in offspring, especially for those born to obese mothers which account for one third of all pregnancies. |
