| First Author | Lv Z | Year | 2024 |
| Journal | Cell Stem Cell | Volume | 31 |
| Issue | 11 | Pages | 1685-1700.e6 |
| PubMed ID | 39232560 | Mgi Jnum | J:378013 |
| Mgi Id | MGI:8277336 | Doi | 10.1016/j.stem.2024.08.005 |
| Citation | Lv Z, et al. (2024) Alveolar regeneration by airway secretory-cell-derived p63(+) progenitors. Cell Stem Cell 31(11):1685-1700.e6 |
| abstractText | Lung injury activates epithelial stem or progenitor cells for alveolar repair and regeneration. Unraveling the origin and fate of injury-induced progenitors is crucial for elucidating lung repair mechanisms. Here, we report that p63-expressing progenitors emerge upon bleomycin-induced mouse lung injury. Single-cell RNA sequencing and clonal analysis reveal that these p63(+) progenitors proliferate rapidly and differentiate into alveolar type 1 and type 2 cells through different trajectories. Dual recombinase-mediated sequential genetic-lineage tracing demonstrates that p63(+) progenitors originate from airway secretory cells and subsequently generate alveolar cells. Functionally, p63 activation is essential for efficient alveolar regeneration from secretory cells post injury. Our study identifies secretory-cell-derived p63(+) progenitors as contributors to alveolar repair, suggesting a potential therapeutic avenue for lung regeneration following injury. |
