| First Author | Meera Khan P | Year | 1984 |
| Journal | Cytogenet Cell Genet | Volume | 37 (1-4) |
| Pages | 537-538 (Abstr.) (399-616) | Mgi Jnum | J:4786 |
| Mgi Id | MGI:53268 | Citation | Meera Khan P, et al. (1984) Gene map of dog: six conserved and three disrupted syntenies (Abstracts of meeting presentations: Human gene mapping 7, Los Angeles Conference (1983) Seventh International Workshop on Human Gene Mapping). Cytogenet Cell Genet 37 (1-4):537-538 (Abstr.) (399-616) |
| abstractText | Full text of Abstract: Abstracts of meeting presentations. Gene map of dog: six conserved and three disrupted syntenies. P. Meera Khan,1 C. Brahe,2 and L.M.M. Wijnen1 1Rijksuniversiteit, Leiden, and 2Univ. Cattolica del Sacro Cuore, Roma Earlier work on rodent-canine somatic cell hybrids has revealed the following syntenies: GAPD-TPI-LDHB and G6PD-HPRT (HGM 4; 547, 1977). During the present study a set of 35 enzyme loci segregating in a series of 26 dog-Chinese hamster somatic cell hybrid clones, were found to be scattered on 25 autosomes and the X chromosome in Canis familiaris (2n = 78). Since no attempts were made to identify the individual canine chromosomes in this study, the putative dog autosomes segregating in the hybrids have been tentatively designated as Ul to U25 (U for unidentified) in the following comparisons between the homologues of man (HSA) and dog (CFA) (HSA No.: CFA UNo.). 1 (EN01-PGD-PGM1-GUK1-PEPC):Ul (ENOl-PGD)/U2 (PGM1)/U3 (GUK1) / (U4 (PEPC ); 2 (ACP1-MDH1-IDH1):U5 (ACP1)/U6 (MDH1)/U7 (IDH1); 3 (ACY1-GPX1):U8 (ACYl-GPX18); 4 (PGM2):U9 (PGM2); 6 (PGM3 Ð ME1 Ð SOD2):U10 (PGM3 Ð ME1 Ð SOD2); 7 (MDH2):U11(MDH2); 9 (AK3):U12(AK3); 10 (PPA): U13 (PPA); 11 (LDHA-ACP2-ESA4): U14 (LDHA)/U15 (ACP2) / U16 (ESA4); 12 (GAPD-TPI-LDHB:) U17 (GAPD-TPI-LDHB); 13 (ESD): U18 (ESD); 14 (NP): U19 (NP) ; 15 (M-P1-PKM2): U20 (MPI-PKM2); 16 (PGP): U21 (PGP); 19 (GPI): U22 (GPI); 20 (ITPA): U23 (ITPA); 21 (SOD1): U24 (SOD1); 22 (ACO2): U25 (ACO2); X(GLA-HPRT-G6PD):CFA X(GLA-HPRT-G6PD). The syntenies Ul,U8, U10, U17, U20, and X appear to have been conserved during the evolution of both man and dog for more than 100 million years. The (iso-arm) human syntenies PGD-PGMl , ACPl-MDHl and LDHA-ACP2 reported to have been preserved in the cat (HGM 6: 213, 1981) seem to be disrupted probably at the emergence of Canoidea and Feloidea from Fissipeda during the evolutionary history of domestic dog. More over, these data also indicate that the feline syntenic groups B3 and C1 (Science 216:257,1982) are represented respectively in 2(U19/U20) and 3(U1/U2/U7) separate canine chromosomes. "De novo" syntenies (which were not found so far in other mammals) have not been observed in the dog during the present study. |
