| First Author | Hsieh CL | Year | 1989 |
| Journal | Cytogenet Cell Genet | Volume | 51 |
| Pages | 1016 (Abstr.) | Mgi Jnum | J:12494 |
| Mgi Id | MGI:60739 | Citation | Hsieh CL, et al. (1989) The gene for the ubiquitous octamer-binding protein Oct-1 is on human Chromosome 1, region cen-q32, and on mouse Chromosome 1. Cytogenet Cell Genet 51:1016 (Abstr.) |
| abstractText | Full text of Abstract: The gene for the ubiquitous octamer-binding protein Oct-1 is on human chromosome 1, region cen-q32, and on mouse chromosome 1. (A2576) CL Hsieh1, R Sturm2, W Herr2, U Francke1. 1HHMI, Beckman Center, Stanford University Medical Center, Stanford, CA; 2Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. Oct-1 is a human promoter-binding protein that recognizes the octameric sequence ATGCAAAT. This protein shares a very similar domain, called POU domain, with the lymphoid-specific transcription factor Oct-2, pituitary-specific transcription factor (Pit-1), and the C. elegans cell lineage gene product unc-86. (Herr et al., Genes & Development 2:1513, 1988). Two subdomains, POU-related homeobox and POU specific box, lie within the POU domain. Unlike other POU-related proteins and other homeobox proteins, OCT1 is ubiquitously expressed. A 90 to 100 kd protein which has the same activity and is variously referred to as OTF-1, NFIII, and OBP100, is probably identical to OCT1. The chromosome localization of the OCT1 gene (Sturm et al., Gene & Development 2:1582, 1988) in humans and mice was determined by Southern blot analyses of 11 human x rodent hybrids and 13 mouse x rodent hybrids. We have mapped this gene to human chromosome 1 and mouse chromosome 1. With a set of hybrids containing partially overlapping regions of chromosome 1 without an intact chromosome 1 present, we have assigned OCT1 to human chromosome 1, region cen-q32. OCT2 has previously been assigned to human chromosome 19 (Ko et al., Cell 55:135, 1988). |
