| First Author | Beechey CV | Year | 1994 |
| Journal | Mouse Genome | Volume | 92 |
| Pages | 86-107 | Mgi Jnum | J:23116 |
| Mgi Id | MGI:71297 | Citation | Beechey CV (1994) Maps of Chromosome Anomalies in the Mouse. Mouse Genome 92:86-107 |
| abstractText | Full text of Mouse Genome contribution: MAPS OF CHROMOSOME ANOMALIES IN THE MOUSE. These maps are based on those of Searle & Beechey (1989) with references from Beechey(1993). The locations of all CURRENTLY AVAILABLE cytologically visible deletions (Del) and duplications (Dp), homogeneously staining regions (Hsr), reciprocal translocations (T), insertions (Is), and transpositions (Tp) are shown on both the G-banding and linkage maps, if known. Tertiary nullisomics (Ns), are also included when the original derivative translocation has been lost (eg Ns(7(15))33Ad.) Robertsonian translocations (Rb) are placed in alphabetical order above the chromosomes concerned. Extinct chromosome anomalies are not included, nor are inversions unless they are pericentric, eg In(Ypq)Lub, associated with a translocation, eg T(In)44H, or an Hsr, eg In(Hsr)lLub. The G-banded maps are drawn from Evans (1989), and these show a further 100 bands and other band size differences from Nesbitt & Francke (1973). The estimated lengths of the linkage map for each chromosome were obtained by using Evans' estimate of the percentages of the female haploid genome per chromosome multiplied by the assumed total map length of 1600 cM. For the actual drawings 1 cM equals 1.22 mrn. The linkage maps show only the marker loci that have been used to map chromosome anomalies or loci involved in deletions, with their distances in cM from the centromere. Distances are derived from Hillyard et al(1993). The abbreviated symbol of each chromosome anomaly has been placed, as far as possible, opposite the Gband in which its breakpoint lies, with lines to this band and, if appropriate, to its position on the linkage map. Unless the reference gives the position of the breakpoint within a band (eg T2Wa is distally located in 2H3) the line covers the whole band (or bands) within which the breakpoint lies. Insertions, pericentric inversions, and inversions associated with a translocation or an HSR have a line on the G-banding map connecting all the bands involved with corresponding lines to the loci they are known to include. Cytologically visible deletions are shown on the right of the G-banding map with a line showing deleted bands. If a specific locus (or loci) is known to be involved, the deletion name is also given on the left of the linkage map in the appropriate position with a bracket showing any other loci also known to be deleted. Cytologically visible duplications are also shown on the right of the G-banding map, the position and staining characteristics of the duplicated segment being illustrated by the appropriate shading/hatching. Whereas terminally positioned examples are distal or proximal extensions of the "original" chromosome, in the case of interstitial duplications it is not possible to ascertain which is the "original" chromosome segment and whether the duplication extends proximally or distally. Unmapped chromosomal anomalies are placed at the bottom of the G-banded maps. Breakpoints on the linkage map are bracketed if the position is uncertain. Short arms have been placed on all chromosomes except 1 and 7 (Grzeschik & Kim, 1976). The other chromosome involved in each anomaly is listed below each map if applicable. These maps will be continually updated, and I should appreciate being told of any errors, omissions, further linkage or banding information, and if any anomalies shown are extinct. Colin Beechey 1994. Beechey, CV (1993) Mouse Genome 91:300-309. Evans, EP (1989) In Lyon, MF & Searle, AG. Genetic Variants and Strains of the Laboratory Mouse, 2nd ed. Oxford University Press: pp 576-578. Grzeschik, K-H & Kim, MA (1976) Chromosomes Today 5:361-365. Hillyard, AC, Doolittle, DP, Davisson, MT, & Roderick, TH (1993) Mouse Genome 91:15-39. Nesbitt, MN & Francke U (1973) Chromosoma 41: 145-158. Searle, AG & Beechey, CV (1989) In Lyon, MF & Searle, AG. Genetic Variants and Strains of the Laboratory Mouse, 2nd ed. Oxford University Press: pp 620-625. Acknowledgement I should like to thank Dr EP Evans for much helpful advice and allowing me to use his G-banded idiogram and band measurements. |
