| First Author | Fukushima Y | Year | 1989 |
| Journal | Cytogenet Cell Genet | Volume | 51 |
| Pages | 1001 (Abstr.) | Mgi Jnum | J:44125 |
| Mgi Id | MGI:1099376 | Citation | Fukushima Y, et al. (1989) Localization of the human gastric inhibitory polypeptide gene (GIP) to Chromosome 17q21.3-q22. Cytogenet Cell Genet 51:1001 (Abstr.) |
| abstractText | Full text of Abstract: Localization of the human gastric inhibitory polypeptide gene (GIP) to chromosome 17q21.3-q22 (A2234). Y Fukushima1, MG Byers1, RL Eddy1, LL Haley1, WM Henry1, N. Inagaki3, Y Seino3, J Takeda3, H Yano3, Y Yamada3, H Imura3, GI Bell2, TB Shows1. 1Roswell Park Memorial Institute, Human Genetics Department, 666 Elm St., Buffalo, NY 14263; 2Howard Hughes Medical Institute, The University of Chicago, 5841 S. Maryland Ave., Box 391, Chicago, IL 60637; 3Kyoto University School of Medicine, Division of Metabolism and Clinical Nutrition, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606, Japan. Gastric inhibitory polypeptide (GIP) is a 42 amino acid hormone secreted by cells of the small intestine which stimulates insulin secretion but only in the presence of glucose, suggesting that it could have a role in the maintenance of plasma glucose levels. The characterization of cDNA clones encoding this hormone indicate that it is derived by proteolytic processing of a 153 amino acid precursor (Takeda et al., 1987). The GIP cDNA hybridized to human DNA fragments and co-segregated with human chromosome 17 in a panel of reduced somatic cell hybrids. Hybridization to DNA from a cell hybrid panel composed of segments of chromosome 17 indicated that the GIP gene was encoded in the 17p11.2-qter region. In situ hybridization to human prometaphase chromosomes confirmed this chromosomal assignment and further localized GIP to 17q21.3-q2Z |
