| First Author | Yum HW | Year | 2017 |
| Journal | Biochem Biophys Res Commun | Volume | 487 |
| Issue | 4 | Pages | 847-855 |
| PubMed ID | 28456627 | Mgi Jnum | J:288375 |
| Mgi Id | MGI:6102346 | Doi | 10.1016/j.bbrc.2017.04.140 |
| Citation | Yum HW, et al. (2017) Constitutive omega-3 fatty acid production in fat-1 transgenic mice and docosahexaenoic acid administration to wild type mice protect against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Biochem Biophys Res Commun 487(4):847-855 |
| abstractText | Omega-3 (omega-3) polyunsaturated fatty acids (PUFAs) are known to have strong anti-inflammatory effects. In the present study, we investigated the protective effects of omega-3 PUFAs on experimentally induced murine colitis. Intrarectal administration of 2.5% 2,4,6-trinitrobenzene sulfonic acid (TNBS) caused inflammation in the colon of wild type mice, but this was less severe in fat-1 transgenic mice that constitutively produce omega-3 PUFAs from omega-6 PUFAs. The intraperitoneal administration of docosahexaenoic acid (DHA), a representative omega-3 PUFA, was also protective against TNBS-induced murine colitis. In addition, endogenously formed and exogenously introduced omega-3 PUFAs attenuated the production of malondialdehyde and 4-hydroxynonenal in the colon of TNBS-treated mice. The effective protection against inflammatory and oxidative colonic tissue damages in fat-1 and DHA-treated mice was associated with suppression of NF-kappaB activation and cyclooxygenase-2 expression and with elevated activation of Nrf2 and upregulation of its target gene, heme oxygenase-1. Taken together, these results provide mechanistic basis of protective action of omega-3 fatty PUFAs against experimental colitis. |
