| First Author | Mohan H | Year | 2023 |
| Journal | Nat Neurosci | Volume | 26 |
| Issue | 3 | Pages | 481-494 |
| PubMed ID | 36690901 | Mgi Jnum | J:379248 |
| Mgi Id | MGI:7486673 | Doi | 10.1038/s41593-022-01244-w |
| Citation | Mohan H, et al. (2023) Cortical glutamatergic projection neuron types contribute to distinct functional subnetworks. Nat Neurosci 26(3):481-494 |
| abstractText | The cellular basis of cerebral cortex functional architecture remains not well understood. A major challenge is to monitor and decipher neural network dynamics across broad cortical areas yet with projection-neuron-type resolution in real time during behavior. Combining genetic targeting and wide-field imaging, we monitored activity dynamics of subcortical-projecting (PT(Fezf2)) and intratelencephalic-projecting (IT(PlxnD1)) types across dorsal cortex of mice during different brain states and behaviors. IT(PlxnD1) and PT(Fezf2) neurons showed distinct activation patterns during wakeful resting, during spontaneous movements and upon sensory stimulation. Distinct IT(PlxnD1) and PT(Fezf2) subnetworks were dynamically tuned to different sensorimotor components of a naturalistic feeding behavior, and optogenetic inhibition of ITs(PlxnD1) and PTs(Fezf2) in subnetwork nodes disrupted distinct components of this behavior. Lastly, IT(PlxnD1) and PT(Fezf2) projection patterns are consistent with their subnetwork activation patterns. Our results show that, in addition to the concept of columnar organization, dynamic areal and projection-neuron-type specific subnetworks are a key feature of cortical functional architecture linking microcircuit components with global brain networks. |
