| First Author | Barral J | Year | 2016 |
| Journal | Nat Neurosci | Volume | 19 |
| Issue | 12 | Pages | 1690-1696 |
| PubMed ID | 27749827 | Mgi Jnum | J:365823 |
| Mgi Id | MGI:8188288 | Doi | 10.1038/nn.4415 |
| Citation | Barral J, et al. (2016) Synaptic scaling rule preserves excitatory-inhibitory balance and salient neuronal network dynamics. Nat Neurosci 19(12):1690-1696 |
| abstractText | The balance between excitation and inhibition (E-I balance) is maintained across brain regions though the network size, strength and number of synaptic connections, and connection architecture may vary substantially. We use a culture preparation to examine the homeostatic synaptic scaling rules that produce E-I balance and in vivo-like activity. We show that synaptic strength scales with the number of connections K as approximately , close to the ideal theoretical value. Using optogenetic techniques, we delivered spatiotemporally patterned stimuli to neurons and confirmed key theoretical predictions: E-I balance is maintained, active decorrelation occurs and the spiking correlation increases with firing rate. Moreover, the trial-to-trial response variability decreased during stimulation, as observed in vivo. These results-obtained in generic cultures, predicted by theory and observed in the intact brain-suggest that the synaptic scaling rule and resultant dynamics are emergent properties of networks in general. |
