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Publication : The synaptic architecture of layer 5 thick tufted excitatory neurons in mouse visual cortex.

First Author	Bodor AL	Year	2025
Journal	Nat Neurosci	Volume	28
Issue	8	Pages	1704-1715
PubMed ID	40721677	Mgi Jnum	J:379320
Mgi Id	MGI:8279207	Doi	10.1038/s41593-025-02004-2
Citation	Bodor AL, et al. (2025) The synaptic architecture of layer 5 thick tufted excitatory neurons in mouse visual cortex. Nat Neurosci 28(8):1704-1715

abstractText

Despite significant progress in characterizing neocortical cell types, a complete understanding of the synaptic connections of individual excitatory cells remains elusive. This study investigates the connectivity of mouse visual cortex thick tufted layer 5 pyramidal cells, also known as extratelencephalic neurons (L5-ETns), using a 1 mm(3) publicly available electron microscopy dataset. The analysis reveals that, in their immediate vicinity, L5-ETns primarily establish connections with a group of inhibitory cell types, which, in turn, specifically target the L5-ETns back. The most common excitatory targets of L5-ETns are layer 5 intertelencephalic neurons (L5-ITns) and layer 6 (L6) pyramidal cells, whereas synapses with other L5-ETns are less common. When L5-ETns extend their axons to other cortical regions, they tend to connect more with excitatory cells. Our results highlight a circuit motif where a subclass of excitatory cells forms a subcircuit with specific inhibitory cell types. This is achieved using a publicly available, automated approach for synapse recognition and automated cell typing, offering a framework for exploring the connectivity of other neuron types.

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