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Allele : Sftpc<tm1Mfbs> surfactant associated protein C; targeted mutation 1, Michael F Beers
Primary Identifier  MGI:6360467 Allele Type  Targeted
Attribute String  Conditional ready, Epitope tag, Humanized sequence, Hypomorph Gene  Sftpc
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  Sequence coding for an N-terminal hemagglutinin (HA) tag was inserted into exon 1 immediately after the ATG start codon, isoleucine codon 73 (ATC) in exon 3 was changed to threonine (p.I73T), and an FRT site flanked neomycin resistance gene and gb2-promoter-driven kanamycin resistance gene cassette into intron 1. The neo/kana cassette interferes with the expression of the gene and mRNA expression is at 15%.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • Sftpc<I73T-neo>,
  • Sftpc<I73T-neo>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Genotypes/models

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

5 Publication categories





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