| First Author | Marshall PR | Year | 2024 |
| Journal | J Neurosci | Volume | 44 |
| Issue | 15 | PubMed ID | 38418220 |
| Mgi Jnum | J:371377 | Mgi Id | MGI:7730970 |
| Doi | 10.1523/JNEUROSCI.0093-23.2024 | Citation | Marshall PR, et al. (2024) DNA G-Quadruplex Is a Transcriptional Control Device That Regulates Memory. J Neurosci 44(15) |
| abstractText | The conformational state of DNA fine-tunes the transcriptional rate and abundance of RNA. Here, we report that G-quadruplex DNA (G4-DNA) accumulates in neurons, in an experience-dependent manner, and that this is required for the transient silencing and activation of genes that are critically involved in learning and memory in male C57/BL6 mice. In addition, site-specific resolution of G4-DNA by dCas9-mediated deposition of the helicase DHX36 impairs fear extinction memory. Dynamic DNA structure states therefore represent a key molecular mechanism underlying memory consolidation.One-Sentence Summary: G4-DNA is a molecular switch that enables the temporal regulation of the gene expression underlying the formation of fear extinction memory. |
