| Primary Identifier | MGI:6739829 | Allele Type | Targeted |
| Attribute String | Null/knockout, Recombinase | Gene | Cpne7 |
| Transmission | Germline | Strain of Origin | C57BL/6 |
| Is Recombinase | true | Is Wild Type | false |
| molecularNote | Via homologous recombination in ES cells, the targeting vector inserted a nuclear localization sequence(NLS)-Cre-FRT-PGK-gb2-neo-FRT cassette (Cre cassette) downstream of the Cpne7 promoter. The PGK-Neo cassette was removed by crossing mice with CAG-FLPe mice. The western blot of whole brain samples did not show the detectable level of Cpne7 protein in homozygous mice. It is a null allele. |
