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Allele : Tg(Tmc1-Tmc2/Tmc1*)1Ajg transgene insertion 1, Andrew J Griffith
Primary Identifier  MGI:7865855 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(Tmc1-Tmc2/Tmc1*)1Ajg
Strain of Origin  C57BL/6J Is Recombinase  false
Is Wild Type  false
molecularNote  BAC clone MSMg01-526L10 (181,748 bp, Riken Bioresource Center DNA Bank, Tsukuba, Japan), encoding wild-type MSM/Ms mouse genomic Tmc1 (170,745 bp) was used to construct Tg[Tmc1deltaEx8_9], Tg[PTmc1::Tmc2] using the Counter-Selection BAC Modification Kit with Red/ET recombination technology (Gene Bridges, Heidelberg, Germany). To construct Tg[Tmc1deltaEx8_9], 2775 bp including exons 8 and 9 were deleted using the same method. To construct Tg[PTmc1::Tmc2], Tg[Tmc1deltaEx8_9] was modified to replace the translation initiation codon of Tmc1 with the Tmc2 cDNA (NM_138655.1) conjugated with the SV40 polyadenylation signal, respectively.
  • mutations:
  • Insertion
  • synonyms:
  • Tg[P(Tmc1)::Tmc2],
  • Tg[P(Tmc1)::Tmc2]
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