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Allele : Gt(ROSA)26Sor<em2(CAG-Syp*,-mCherry)Ddg> gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 2, David D Ginty
Primary Identifier  MGI:8235815 Allele Type  Endonuclease-mediated
Attribute String  Conditional ready, Reporter Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  129S4/SvJae
Is Recombinase  false Is Wild Type  false
molecularNote  A CAG-FRT-Stop (hGH pA, HSV TK pA)-FRT-loxP-Stop (SV40 pA x3)-loxP-rat Syp cDNA-miniSOG-T2A-mCherry cassette was targeted to intron 1 of the mouse Gt(ROSA)26Sor gene using CRISPR-based homologous recombination techniques. The Syp-miniSOG-T2A-mCherry cassette consists of cDNA encoding rat synaptophysin (Syp) fused to miniSOG and a Thosea asigna virus 2A (T2A) sequence, followed by in frame with mCherry at the 3' end. The miniSOG (mini singlet oxygen generator) component is a small (106-residue) green fluorescent flavoprotein that efficiently generates singlet oxygen when illuminated by blue light.
  • mutations:
  • Insertion
  • synonyms:
  • Rosa26<FSF-LSL-SYP1-miniSOG-mcherry>,
  • Rosa26<FSF-LSL-SYP1-miniSOG-mcherry>
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