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Allele : Dmxl1<em2Rstot> Dmx-like 1; endonuclease-mediated mutation 2, Rolf Stottmann
Primary Identifier  MGI:8293347 Allele Type  Endonuclease-mediated
Attribute String  Not Specified Gene  Dmxl1
Strain of Origin  C57BL/6NCrl Is Recombinase  false
Is Wild Type  false
molecularNote  CRISPR-targeting introduced the mutation (TTT to TCT) responsible for the amino acid substitution of phenylalanine with cysteine at position 1729 (F1729C). Quantitative real-time PCR analysis of craniofacial tissues at E13.5 shows a ~25% reduction of Dmxl1 expression in heterozygous embryos, and a mild (~22%) increase of Dmxl1 expression in homozygous embryos.
  • mutations:
  • Single point mutation
  • synonyms:
  • Dmxl1<F1729C>,
  • Dmxl1<F1729C>
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Trail: Allele




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