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GO Term : symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity [GO:0039554] Gene Ontology
Namespace  biological_process Obsolete  false
description  A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
  • synonyms:
  • suppression by virus of host MDA-5 signalling pathway,
  • Inhibition of host MDA5 by virus,
  • GO:0039539,
  • suppression by virus of host MDA-5 signaling pathway,
  • inhibition by virus of host MDA-5 signaling,
  • suppression by virus of host MDA-5 activity,
  • suppression by virus of host IFIH1 signaling pathway,
  • suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity,
  • inhibition of host IFIH1/MDA5 by virus
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