Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate.
synonyms:
3',5'-cyclic-AMP phosphodiesterase inhibitor,
negative regulation of 3',5'-cyclic-AMP phosphodiesterase activity,
negative regulation of cyclic nucleotide phosphodiesterase activity,
phosphodiesterase inhibitor,
inhibition of cyclic nucleotide phosphodiesterase activity,
negative regulation of cGMP phosphodiesterase activity,
downregulation of cyclic nucleotide phosphodiesterase activity,
negative regulation of cAMP phosphodiesterase activity,
cAMP phosphodiesterase inhibitor,
negative regulation of 3',5' cyclic nucleotide phosphodiesterase activity,
