Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate.
synonyms:
down-regulation of cyclic nucleotide phosphodiesterase activity,
inhibition of cyclic nucleotide phosphodiesterase activity,
3',5'-cyclic-AMP phosphodiesterase inhibitor,
phosphodiesterase inhibitor,
down regulation of cyclic nucleotide phosphodiesterase activity,
