| First Author | Hart CP | Year | 1985 |
| Journal | Cell | Volume | 43 |
| Issue | 1 | Pages | 9-18 |
| PubMed ID | 3000607 | Mgi Jnum | J:8129 |
| Mgi Id | MGI:56598 | Doi | 10.1016/0092-8674(85)90007-8 |
| Citation | Hart CP, et al. (1985) Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus. Cell 43(1):9-18 |
| abstractText | The homeo box is a 180 bp protein-coding domain found within homeotic genes of Drosophila and conserved in a variety of invertebrate and vertebrate species. It has been suggested that the mammalian homeo box sequences may play a role in controlling pattern formation during embryogenesis. We report findings that support this hypothesis. We have cloned three overlapping recombinant phage clones that cover a region of mouse chromosome 11 that contains a cluster of four homeo boxes (the Hox-2 locus). This locus encodes multiple transcripts that are expressed during embryogenesis. Forty kilobases of the Hox-2 region is devoid of repetitive elements and shows extensive homology with the human Hox-2 locus. These results provide direct evidence for genetic expression during embryonic development, a conserved organization in comparison to the cognate human locus, and a complexity of organization and transcript expression similar to that found in Drosophila. |
