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Search results 1 to 100 out of 114 for Scap

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Category: Publication
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Type Details Score
Publication
11358865 | J:69592
First Author: Matsuda M
Year: 2001
Journal: Genes Dev
Title: SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation.
Volume: 15
Issue: 10
Pages: 1206-16
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Publication
21454655 | -
First Author: Motamed M
Year: 2011
Journal: J Biol Chem
Title: Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis.
Volume: 286
Issue: 20
Pages: 18002-12
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Publication
19948958 | J:155526
First Author: Verheijen MH
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: SCAP is required for timely and proper myelin membrane synthesis.
Volume: 106
Issue: 50
Pages: 21383-8
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Publication
25896350 | J:225543
First Author: McFarlane MR
Year: 2015
Journal: J Lipid Res
Title: Scap is required for sterol synthesis and crypt growth in intestinal mucosa.
Volume: 56
Issue: 8
Pages: 1560-71
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Publication
16054043 | J:129815
First Author: Kuriyama H
Year: 2005
Journal: Cell Metab
Title: Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver.
Volume: 1
Issue: 1
Pages: 41-51
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Publication
26900919 | J:247225
First Author: Chen W
Year: 2016
Journal: PLoS Pathog
Title: ER Adaptor SCAP Translocates and Recruits IRF3 to Perinuclear Microsome Induced by Cytosolic Microbial DNAs.
Volume: 12
Issue: 2
Pages: e1005462
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Publication
33227706 | J:308923
 
First Author: Li Z
Year: 2021
Journal: Biomed Pharmacother
Title: SCAP knockout in SM22α-Cre mice induces defective angiogenesis in the placental labyrinth.
Volume: 133
Pages: 111011
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Publication
37024487 | J:334528
First Author: Zheng G
Year: 2023
Journal: Cell Death Dis
Title: SCAP contributes to embryonic angiogenesis by negatively regulating KISS-1 expression in mice.
Volume: 14
Issue: 4
Pages: 249
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Publication
19074148 | J:147592
First Author: Besnard V
Year: 2009
Journal: J Biol Chem
Title: Deletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts.
Volume: 284
Issue: 6
Pages: 4018-30
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Publication
23585733 | J:197684
First Author: Suzuki R
Year: 2013
Journal: PLoS Biol
Title: Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function.
Volume: 11
Issue: 4
Pages: e1001532
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Publication
30462530 | J:288003
First Author: Li D
Year: 2019
Journal: FASEB J
Title: SCAP knockdown in vascular smooth muscle cells alleviates atherosclerosis plaque formation via up-regulating autophagy in ApoE-/- mice.
Volume: 33
Issue: 3
Pages: 3437-3450
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Publication
29899135 | J:264124
 
First Author: Tsushima H
Year: 2018
Journal: Development
Title: Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis.
Volume: 145
Issue: 13
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Publication
12242332 | J:79403
First Author: Yabe D
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.
Volume: 99
Issue: 20
Pages: 12753-8
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Publication
17428920 | -
First Author: Radhakrishnan A
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig.
Volume: 104
Issue: 16
Pages: 6511-8
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Publication
15797383 | -
First Author: Hughes AL
Year: 2005
Journal: Cell
Title: SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast.
Volume: 120
Issue: 6
Pages: 831-42
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Publication
22751013 | J:211761
First Author: Camargo N
Year: 2012
Journal: FASEB J
Title: High-fat diet ameliorates neurological deficits caused by defective astrocyte lipid metabolism.
Volume: 26
Issue: 10
Pages: 4302-15
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Publication
35380992 | J:325010
 
First Author: Kawamura S
Year: 2022
Journal: J Clin Invest
Title: Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis.
Volume: 132
Issue: 11
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Publication
29068315 | J:249975
   
First Author: Zhang L
Year: 2017
Journal: Elife
Title: Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP.
Volume: 6
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Publication
22326225 | J:182284
First Author: Moon YA
Year: 2012
Journal: Cell Metab
Title: The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals.
Volume: 15
Issue: 2
Pages: 240-6
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Publication
27866836 | J:251961
First Author: Papazyan R
Year: 2016
Journal: Cell Metab
Title: Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP.
Volume: 24
Issue: 6
Pages: 863-874
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Publication
37267109 | J:341034
First Author: Fei X
Year: 2023
Journal: Cell Rep
Title: The Scap-SREBP1-S1P/S2P lipogenesis signal orchestrates the homeostasis and spatiotemporal activation of NF-κB.
Volume: 42
Issue: 6
Pages: 112586
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Publication
27601673 | J:238350
First Author: Shimizu-Albergine M
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: SCAP/SREBP pathway is required for the full steroidogenic response to cyclic AMP.
Volume: 113
Issue: 38
Pages: E5685-93
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Publication
24806461 | J:216084
First Author: Bridges JP
Year: 2014
Journal: PLoS One
Title: Epithelial SCAP/INSIG/SREBP signaling regulates multiple biological processes during perinatal lung maturation.
Volume: 9
Issue: 5
Pages: e91376
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Publication
20739508 | J:170224
First Author: Rudolph MC
Year: 2010
Journal: Am J Physiol Endocrinol Metab
Title: Sterol regulatory element binding protein and dietary lipid regulation of fatty acid synthesis in the mammary epithelium.
Volume: 299
Issue: 6
Pages: E918-27
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Publication
27137100 | J:344770
 
First Author: Hashimoto M
Year: 2016
Journal: J Steroid Biochem Mol Biol
Title: Cyp3a deficiency enhances androgen receptor activity and cholesterol synthesis in the mouse prostate.
Volume: 163
Pages: 121-8
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Publication
28920951 | J:305308
First Author: Assmann N
Year: 2017
Journal: Nat Immunol
Title: Srebp-controlled glucose metabolism is essential for NK cell functional responses.
Volume: 18
Issue: 11
Pages: 1197-1206
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Publication
37244259 | J:337727
First Author: Yan C
Year: 2023
Journal: Cancer Cell
Title: Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity.
Volume: 41
Issue: 7
Pages: 1276-1293.e11
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Publication
21195348 | J:169478
First Author: Tang JJ
Year: 2011
Journal: Cell Metab
Title: Inhibition of SREBP by a small molecule, betulin, improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques.
Volume: 13
Issue: 1
Pages: 44-56
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Publication
26686653 | J:227982
First Author: York AG
Year: 2015
Journal: Cell
Title: Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling.
Volume: 163
Issue: 7
Pages: 1716-29
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Publication
31303399 | J:282652
First Author: Kusnadi A
Year: 2019
Journal: Immunity
Title: The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair.
Volume: 51
Issue: 2
Pages: 241-257.e9
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Publication
31270208 | J:281312
First Author: Xiaoli AM
Year: 2019
Journal: J Biol Chem
Title: Lipogenic SREBP-1a/c transcription factors activate expression of the iron regulator hepcidin, revealing cross-talk between lipid and iron metabolisms.
Volume: 294
Issue: 34
Pages: 12743-12753
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Publication
17666524 | J:128622
First Author: Li J
Year: 2007
Journal: Physiol Genomics
Title: Effect of deficiency in SREBP cleavage-activating protein on lipid metabolism during intermittent hypoxia.
Volume: 31
Issue: 2
Pages: 273-80
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Publication
28846071 | J:252691
First Author: Rong X
Year: 2017
Journal: J Clin Invest
Title: ER phospholipid composition modulates lipogenesis during feeding and in obesity.
Volume: 127
Issue: 10
Pages: 3640-3651
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Publication
22337502 | J:181551
First Author: Verdier V
Year: 2012
Journal: Glia
Title: Aging of myelinating glial cells predominantly affects lipid metabolism and immune response pathways.
Volume: 60
Issue: 5
Pages: 751-60
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Publication
23563690 | J:196681
First Author: Kidani Y
Year: 2013
Journal: Nat Immunol
Title: Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity.
Volume: 14
Issue: 5
Pages: 489-99
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Publication
28747429 | J:244377
     
First Author: Zhang Y
Year: 2017
Journal: Genes Dev
Title: The hepatic circadian clock fine-tunes the lipogenic response to feeding through RORα/γ.
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Publication
14512514 | J:86192
First Author: Horton JD
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes.
Volume: 100
Issue: 21
Pages: 12027-32
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Publication
37066875 | J:335125
 
First Author: Guan D
Year: 2023
Journal: J Clin Invest
Title: Hepatocyte SREBP signaling mediates clock communication within the liver.
Volume: 133
Issue: 8
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Publication
32694855 | J:321860
First Author: Gong XM
Year: 2019
Journal: Nat Metab
Title: Gpnmb secreted from liver promotes lipogenesis in white adipose tissue and aggravates obesity and insulin resistance.
Volume: 1
Issue: 5
Pages: 570-583
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Publication
25593129 | J:241200
First Author: Tarling EJ
Year: 2015
Journal: Arterioscler Thromb Vasc Biol
Title: The nuclear receptor FXR uncouples the actions of miR-33 from SREBP-2.
Volume: 35
Issue: 4
Pages: 787-95
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Publication
27251289 | J:233670
First Author: Sallam T
Year: 2016
Journal: Nature
Title: Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis.
Volume: 534
Issue: 7605
Pages: 124-8
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Publication
28244871 | J:241873
   
First Author: Rong S
Year: 2017
Journal: Elife
Title: Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice.
Volume: 6
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Publication
30057115 | J:272719
First Author: Guan D
Year: 2018
Journal: Cell
Title: Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes.
Volume: 174
Issue: 4
Pages: 831-842.e12
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Publication
30530672 | J:269257
First Author: Lee JH
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: SREBP-1a-stimulated lipid synthesis is required for macrophage phagocytosis downstream of TLR4-directed mTORC1.
Volume: 115
Issue: 52
Pages: E12228-E12234
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Publication
28549068 | J:244979
First Author: Camargo N
Year: 2017
Journal: PLoS Biol
Title: Oligodendroglial myelination requires astrocyte-derived lipids.
Volume: 15
Issue: 5
Pages: e1002605
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Publication
31451658 | J:279346
First Author: Adlanmerini M
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Circadian lipid synthesis in brown fat maintains murine body temperature during chronic cold.
Volume: 116
Issue: 37
Pages: 18691-18699
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Publication
11842132 | J:72264
First Author: Wittenburg H
Year: 2002
Journal: Physiol Genomics
Title: Interacting QTLs for cholesterol gallstones and gallbladder mucin in AKR and SWR strains of mice.
Volume: 8
Issue: 1
Pages: 67-77
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Publication
14592843 | J:86340
First Author: Korstanje R
Year: 2004
Journal: Arterioscler Thromb Vasc Biol
Title: Quantitative trait locus mapping of genes that regulate phospholipid transfer activity in SM/J and NZB/BlNJ inbred mice.
Volume: 24
Issue: 1
Pages: 155-60
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28784627 | J:243953
First Author: Karmaus PWF
Year: 2017
Journal: J Exp Med
Title: Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF-mediated myelopoiesis.
Volume: 214
Issue: 9
Pages: 2629-2647
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Publication
32514064 | J:306420
First Author: Zhou QD
Year: 2020
Journal: Nat Immunol
Title: Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins.
Volume: 21
Issue: 7
Pages: 746-755
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Publication
32516576 | J:296582
First Author: Hsieh WY
Year: 2020
Journal: Cell Metab
Title: Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome.
Volume: 32
Issue: 1
Pages: 128-143.e5
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Publication
14662765 | J:88490
First Author: Beigneux AP
Year: 2004
Journal: J Biol Chem
Title: ATP-citrate lyase deficiency in the mouse.
Volume: 279
Issue: 10
Pages: 9557-64
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Publication
30604742 | J:270164
First Author: Guo M
Year: 2019
Journal: Nat Commun
Title: Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth.
Volume: 10
Issue: 1
Pages: 37
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Publication
- | J:82718
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Download
Title: MGI cDNA Clone Load
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Publication
- | J:175597
     
First Author: Overbeek PA
Year: 2011
Journal: MGI Direct Data Submission
Title: Direct Data Submission for Overbeek Lentiviral Transgenic Lines
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Publication
16783635 | J:109795
First Author: Kenney-Hunt JP
Year: 2006
Journal: Mamm Genome
Title: Quantitative trait loci for body size components in mice.
Volume: 17
Issue: 6
Pages: 526-37
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15582152 | J:102103
First Author: Jensen P
Year: 2004
Journal: Brain Res Mol Brain Res
Title: A neurogenomics approach to gene expression analysis in the developing brain.
Volume: 132
Issue: 2
Pages: 116-27
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:147112
     
First Author: Taconic
Year: 2006
Journal: MGI Direct Data Submission
Title: Information obtained from Taconic website.
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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First Author: Kong M
Year: 2021
Journal: Front Cell Dev Biol
Title: The Chromatin Remodeling Protein BRG1 Regulates SREBP Maturation by Activating SCAP Transcription in Hepatocytes.
Volume: 9
Pages: 622866
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First Author: Yan R
Year: 2021
Journal: Cell Rep
Title: Structural basis for sterol sensing by Scap and Insig.
Volume: 35
Issue: 13
Pages: 109299
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First Author: Loregger A
Year: 2020
Journal: Nat Commun
Title: Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism.
Volume: 11
Issue: 1
Pages: 1128
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First Author: Espenshade PJ
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER.
Volume: 99
Issue: 18
Pages: 11694-9
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First Author: Yang T
Year: 2002
Journal: Cell
Title: Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.
Volume: 110
Issue: 4
Pages: 489-500
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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