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Search results 1 to 100 out of 510 for Grn

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Type Details Score
Gene
2896 | GRN
Type: gene
Organism: human
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Gene
767942 | GRN
Type: gene
Organism: cattle
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Gene
714851 | GRN
Type: gene
Organism: macaque, rhesus
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Gene
101748909 | GRN
Type: gene
Organism: chicken
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Gene
594884 | grn
Type: gene
Organism: frog, western clawed
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Gene
key_28302 | GRN
Type: gene
Organism: guinea pig
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Gene
29143 | Grn
Type: gene
Organism: rat
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Gene
480501 | GRN
Type: gene
Organism: dog, domestic
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Gene
454728 | GRN
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:95832 | Grn
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
36207292 | J:330010
First Author: Boland S
Year: 2022
Journal: Nat Commun
Title: Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.
Volume: 13
Issue: 1
Pages: 5924
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Publication
33795008 | J:311726
First Author: Frew J
Year: 2021
Journal: Acta Neuropathol Commun
Title: Neuropathological and behavioral characterization of aged Grn R493X progranulin-deficient frontotemporal dementia knockin mice.
Volume: 9
Issue: 1
Pages: 57
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Protein
Q920S1
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: false
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Publication
34450028 | J:314229
First Author: Logan T
Year: 2021
Journal: Cell
Title: Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Volume: 184
Issue: 18
Pages: 4651-4668.e25
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Publication
33028409 | J:308483
First Author: Huang M
Year: 2020
Journal: Acta Neuropathol Commun
Title: Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations.
Volume: 8
Issue: 1
Pages: 163
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Publication
36707901 | J:336032
First Author: Cabron AS
Year: 2023
Journal: Acta Neuropathol Commun
Title: Lack of a protective effect of the Tmem106b "protective SNP" in the Grn knockout mouse model for frontotemporal lobar degeneration.
Volume: 11
Issue: 1
Pages: 21
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Publication
26701296 | J:231178
 
First Author: Petkau TL
Year: 2016
Journal: Neuroscience
Title: Core neuropathological abnormalities in progranulin-deficient mice are penetrant on multiple genetic backgrounds.
Volume: 315
Pages: 175-95
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Publication
20737593 | J:167031
First Author: Petkau TL
Year: 2010
Journal: J Comp Neurol
Title: Progranulin expression in the developing and adult murine brain.
Volume: 518
Issue: 19
Pages: 3931-47
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Publication
37105261 | J:336395
 
First Author: Life B
Year: 2023
Journal: Neurobiol Dis
Title: FTD-associated behavioural and transcriptomic abnormalities in 'humanized' progranulin-deficient mice: A novel model for progranulin-associated FTD.
Volume: 182
Pages: 106138
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Publication
33636385 | J:303265
 
First Author: Petkau TL
Year: 2021
Journal: Neurobiol Dis
Title: Human progranulin-expressing mice as a novel tool for the development of progranulin-modulating therapeutics.
Volume: 153
Pages: 105314
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Publication
28453791 | J:243041
First Author: Beel S
Year: 2017
Journal: Hum Mol Genet
Title: Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.
Volume: 26
Issue: 15
Pages: 2850-2863
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Publication
31291241 | J:277447
First Author: Zhou X
Year: 2019
Journal: PLoS One
Title: Progranulin deficiency leads to reduced glucocerebrosidase activity.
Volume: 14
Issue: 7
Pages: e0212382
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Publication
28778989 | J:244294
First Author: Chang MC
Year: 2017
Journal: J Exp Med
Title: Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation.
Volume: 214
Issue: 9
Pages: 2611-2628
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Publication
23364791 | J:203514
First Author: Nguyen AD
Year: 2013
Journal: J Biol Chem
Title: Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL).
Volume: 288
Issue: 12
Pages: 8627-35
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Publication
31639062 | J:295744
First Author: Nagy D
Year: 2019
Journal: Alzheimers Res Ther
Title: Age-dependent emergence of neurophysiological and behavioral abnormalities in progranulin-deficient mice.
Volume: 11
Issue: 1
Pages: 88
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Publication
23608112 | J:211734
First Author: Herdewyn S
Year: 2013
Journal: Neurobiol Aging
Title: Progranulin does not affect motor neuron degeneration in mutant SOD1 mice and rats.
Volume: 34
Issue: 10
Pages: 2302-3
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Publication
23702345 | J:211725
First Author: Petkau TL
Year: 2013
Journal: Neurobiol Aging
Title: Sensitivity to neurotoxic stress is not increased in progranulin-deficient mice.
Volume: 34
Issue: 11
Pages: 2548-50
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Publication
21092856 | J:167749
First Author: Hu F
Year: 2010
Journal: Neuron
Title: Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.
Volume: 68
Issue: 4
Pages: 654-67
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Publication
21943601 | J:178551
First Author: Rosen EY
Year: 2011
Journal: Neuron
Title: Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling.
Volume: 71
Issue: 6
Pages: 1030-42
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Publication
22062772 | J:182051
First Author: Petkau TL
Year: 2012
Journal: Neurobiol Dis
Title: Synaptic dysfunction in progranulin-deficient mice.
Volume: 45
Issue: 2
Pages: 711-22
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Publication
27356620 | J:240061
 
First Author: Nicholson AM
Year: 2016
Journal: Nat Commun
Title: Prosaposin is a regulator of progranulin levels and oligomerization.
Volume: 7
Pages: 11992
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Publication
22225875 | J:182323
First Author: Matsubara T
Year: 2012
Journal: Cell Metab
Title: PGRN is a key adipokine mediating high fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue.
Volume: 15
Issue: 1
Pages: 38-50
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Publication
28647554 | J:259606
 
First Author: Petkau TL
Year: 2017
Journal: Neurobiol Dis
Title: Conditional loss of progranulin in neurons is not sufficient to cause neuronal ceroid lipofuscinosis-like neuropathology in mice.
Volume: 106
Pages: 14-22
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Publication
28379303 | J:278224
First Author: Arrant AE
Year: 2017
Journal: Brain
Title: Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia.
Volume: 140
Issue: 5
Pages: 1447-1465
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Publication
27213486 | J:242943
First Author: Arrant AE
Year: 2016
Journal: Genes Brain Behav
Title: Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test.
Volume: 15
Issue: 6
Pages: 588-603
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Publication
23699531 | J:198670
First Author: Chen X
Year: 2013
Journal: J Neurosci
Title: Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells.
Volume: 33
Issue: 21
Pages: 9202-13
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Publication
26361634 | J:229416
 
First Author: Arrant AE
Year: 2015
Journal: eNeuro
Title: Effects of Exercise on Progranulin Levels and Gliosis in Progranulin-Insufficient Mice.
Volume: 2
Issue: 3
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Publication
29511098 | J:259651
First Author: Nguyen AD
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay.
Volume: 115
Issue: 12
Pages: E2849-E2858
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Publication
28404863 | J:249641
 
First Author: Ward ME
Year: 2017
Journal: Sci Transl Med
Title: Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.
Volume: 9
Issue: 385
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Publication
31491449 | J:279383
 
First Author: Voshtani R
Year: 2019
Journal: Cancer Lett
Title: Progranulin promotes melanoma progression by inhibiting natural killer cell recruitment to the tumor microenvironment.
Volume: 465
Pages: 24-35
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Publication
25234724 | J:217897
 
First Author: Hafler BP
Year: 2014
Journal: Brain Res
Title: Progressive retinal degeneration and accumulation of autofluorescent lipopigments in Progranulin deficient mice.
Volume: 1588
Pages: 168-74
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Publication
20522652 | J:162098
First Author: Ahmed Z
Year: 2010
Journal: Am J Pathol
Title: Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging.
Volume: 177
Issue: 1
Pages: 311-24
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Publication
38369347 | J:346899
     
First Author: Adachi E
Year: 2024
Journal: Exp Anim
Title: Progranulin deficiency attenuates tubulointerstitial injury in a mouse unilateral ureteral obstruction model.
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Publication
28845019 | J:273933
First Author: Hosokawa M
Year: 2018
Journal: Exp Anim
Title: Progranulin haploinsufficiency reduces amyloid beta deposition in Alzheimer's disease model mice.
Volume: 67
Issue: 1
Pages: 63-70
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Publication
21933710 | J:179838
First Author: Ghoshal N
Year: 2012
Journal: Neurobiol Dis
Title: Core features of frontotemporal dementia recapitulated in progranulin knockout mice.
Volume: 45
Issue: 1
Pages: 395-408
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Publication
15901638 | J:100669
First Author: Qin J
Year: 2005
Journal: Biol Reprod
Title: Effects of progranulin on blastocyst hatching and subsequent adhesion and outgrowth in the mouse.
Volume: 73
Issue: 3
Pages: 434-42
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Publication
20489155 | J:162113
First Author: Wang WX
Year: 2010
Journal: Am J Pathol
Title: miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease.
Volume: 177
Issue: 1
Pages: 334-45
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Publication
28541286 | J:250451
 
First Author: Zhou X
Year: 2017
Journal: Nat Commun
Title: Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations.
Volume: 8
Pages: 15277
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Publication
25261995 | J:227827
First Author: Minami SS
Year: 2014
Journal: Nat Med
Title: Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.
Volume: 20
Issue: 10
Pages: 1157-64
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Publication
23516300 | J:196590
First Author: Filiano AJ
Year: 2013
Journal: J Neurosci
Title: Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice.
Volume: 33
Issue: 12
Pages: 5352-61
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Publication
32929860 | J:298997
First Author: Werner G
Year: 2020
Journal: EMBO Rep
Title: Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice.
Volume: 21
Issue: 10
Pages: e50241
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Publication
28070672 | J:342528
First Author: Takahashi H
Year: 2017
Journal: Acta Neuropathol
Title: Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.
Volume: 133
Issue: 5
Pages: 785-807
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Publication
36618392 | J:332607
 
First Author: Houser MC
Year: 2022
Journal: Front Immunol
Title: Progranulin loss results in sex-dependent dysregulation of the peripheral and central immune system.
Volume: 13
Pages: 1056417
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Publication
23830905 | J:207049
 
First Author: Tanaka Y
Year: 2013
Journal: Neuroscience
Title: Increased lysosomal biogenesis in activated microglia and exacerbated neuronal damage after traumatic brain injury in progranulin-deficient mice.
Volume: 250
Pages: 8-19
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Publication
23201826 | J:194183
 
First Author: Tanaka Y
Year: 2013
Journal: Neuroscience
Title: Exacerbated inflammatory responses related to activated microglia after traumatic brain injury in progranulin-deficient mice.
Volume: 231
Pages: 49-60
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Publication
28728022 | J:250046
First Author: Klein ZA
Year: 2017
Journal: Neuron
Title: Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.
Volume: 95
Issue: 2
Pages: 281-296.e6
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Publication
31122931 | J:284721
 
First Author: Götzl JK
Year: 2019
Journal: EMBO Mol Med
Title: Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.
Volume: 11
Issue: 6
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Publication
22733568 | J:188420
First Author: Wils H
Year: 2012
Journal: J Pathol
Title: Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice.
Volume: 228
Issue: 1
Pages: 67-76
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Publication
25575133 | J:260568
First Author: Hosokawa M
Year: 2015
Journal: J Neuropathol Exp Neurol
Title: Progranulin reduction is associated with increased tau phosphorylation in P301L tau transgenic mice.
Volume: 74
Issue: 2
Pages: 158-65
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Publication
35019161 | J:329542
First Author: Reifschneider A
Year: 2022
Journal: EMBO J
Title: Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency.
Volume: 41
Issue: 4
Pages: e109108
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Publication
29929528 | J:284773
First Author: Arrant AE
Year: 2018
Journal: Mol Neurodegener
Title: Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency.
Volume: 13
Issue: 1
Pages: 32
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Publication
30448285 | J:274800
 
First Author: Arrant AE
Year: 2019
Journal: Neurobiol Dis
Title: Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice.
Volume: 124
Pages: 152-162
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Publication
22781549 | J:330488
 
First Author: Gass J
Year: 2012
Journal: Mol Neurodegener
Title: Progranulin regulates neuronal outgrowth independent of sortilin.
Volume: 7
Pages: 33
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Publication
29378861 | J:258854
First Author: Arrant AE
Year: 2018
Journal: J Neurosci
Title: Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis.
Volume: 38
Issue: 9
Pages: 2341-2358
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Publication
37838007 | J:342031
 
First Author: Kaplelach AK
Year: 2023
Journal: Neurobiol Dis
Title: Regulation of extracellular progranulin in medial prefrontal cortex.
Volume: 188
Pages: 106326
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Publication
34618685 | J:325152
 
First Author: Dong T
Year: 2021
Journal: JCI Insight
Title: Microglia regulate brain progranulin levels through the endocytosis/lysosomal pathway.
Volume: 6
Issue: 22
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Publication
25155018 | J:218705
First Author: Ward ME
Year: 2014
Journal: J Exp Med
Title: Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.
Volume: 211
Issue: 10
Pages: 1937-45
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Publication
28438992 | J:242226
First Author: Krabbe G
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.
Volume: 114
Issue: 19
Pages: 5029-5034
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Protein Coding Gene
MGP_CAROLIEiJ_G0017252 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0019235 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0019203 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0019172 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0019177 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0018986 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_95832 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0019626 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0018540 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0018955 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0019067 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0019057 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0019136 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0019088 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0019664 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0018303 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0018589 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0018382 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0018095 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
8482392 | J:4982
First Author: Baba T
Year: 1993
Journal: FEBS Lett
Title: Exon/intron organization of the gene encoding the mouse epithelin/granulin precursor (acrogranin).
Volume: 322
Issue: 2
Pages: 89-94
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Publication
8471244 | J:32404
First Author: Baba T
Year: 1993
Journal: Mol Reprod Dev
Title: Acrogranin, an acrosomal cysteine-rich glycoprotein, is the precursor of the growth-modulating peptides, granulins, and epithelins, and is expressed in somatic as well as male germ cells.
Volume: 34
Issue: 3
Pages: 233-43
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Publication
12524533 | J:269542
First Author: He Z
Year: 2003
Journal: Nat Med
Title: Progranulin is a mediator of the wound response.
Volume: 9
Issue: 2
Pages: 225-9
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Publication
20026663 | J:156824
First Author: Yin F
Year: 2010
Journal: J Exp Med
Title: Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice.
Volume: 207
Issue: 1
Pages: 117-28
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Publication
28073925 | J:242512
First Author: Tanaka Y
Year: 2017
Journal: Hum Mol Genet
Title: Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.
Volume: 26
Issue: 5
Pages: 969-988
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Publication
30635627 | J:276576
First Author: Öztürk S
Year: 2019
Journal: Leukemia
Title: Rejection of adoptively transferred Eµ-TCL1 chronic lymphocytic leukemia cells in C57BL/6 substrains or knockout mouse lines.
Volume: 33
Issue: 6
Pages: 1514-1539
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Publication
34103390 | J:308451
 
First Author: Du H
Year: 2021
Journal: Life Sci Alliance
Title: A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses.
Volume: 4
Issue: 7
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Publication
28720486 | J:253869
First Author: Hardt S
Year: 2017
Journal: Biochim Biophys Acta
Title: Loss of synaptic zinc transport in progranulin deficient mice may contribute to progranulin-associated psychopathology and chronic pain.
Volume: 1863
Issue: 11
Pages: 2727-2745
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Publication
27629805 | J:258949
 
First Author: Altmann C
Year: 2016
Journal: Neurobiol Dis
Title: Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy.
Volume: 96
Pages: 294-311
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Publication
26206194 | J:228147
First Author: Minami SS
Year: 2015
Journal: Biochem Pharmacol
Title: Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists.
Volume: 97
Issue: 4
Pages: 454-462
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Publication
31959936 | J:287375
First Author: Marschallinger J
Year: 2020
Journal: Nat Neurosci
Title: Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain.
Volume: 23
Issue: 2
Pages: 194-208
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Publication
32792571 | J:299286
First Author: Telpoukhovskaia MA
Year: 2020
Journal: Sci Rep
Title: Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia.
Volume: 10
Issue: 1
Pages: 13688
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Publication
28903038 | J:254838
First Author: Evers BM
Year: 2017
Journal: Cell Rep
Title: Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency.
Volume: 20
Issue: 11
Pages: 2565-2574
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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