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Search results 301 to 358 out of 358 for Drosha

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0.058s

Type

Details

Score

HT Experiment

GSE73824 | Next Generation Sequencing Facilitates Quantitative Analysis of oocyte, sperm, 2PN embryos derived from WT, Dicer cKO and Drosha cKO small non-coding RNAs


Experiment Type:	RNA-Seq
Study Type:	WT vs. Mutant
Source:	GEO

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Publication

20226070 | -

First Author:	Mueller GA
Year:	2010
Journal:	Silence
Title:	Solution structure of the Drosha double-stranded RNA-binding domain.
Volume:	1
Issue:	1
Pages:	2

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Publication

14508493 | -

First Author:	Lee Y
Year:	2003
Journal:	Nature
Title:	The nuclear RNase III Drosha initiates microRNA processing.
Volume:	425
Issue:	6956
Pages:	415-9

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SO Term

SO:0001034 | miRtron

•

SO Term

SO:0001244 | pre_miRNA

•

HT Experiment

GSE64880 | RNA expression in mutants of the miRNA pathway during myelination


Experiment Type:	RNA-Seq
Study Type:	WT vs. Mutant
Source:	GEO

•

Protein

A0A338P691

Organism:	Mus musculus/domesticus
Length:	108
Fragment?:	true

•

Publication

26027739 | -

First Author:	Nguyen TA
Year:	2015
Journal:	Cell
Title:	Functional Anatomy of the Human Microprocessor.
Volume:	161
Issue:	6
Pages:	1374-87

•

Protein Domain

IPR040375 | DGCR8

Type:

Family

Description:

Primary microRNA transcripts (pri-miRs) are cleaved by Microprocessor, a complex containing RNase III DROSHA and its cofactor DGCR8 []. DGCR8 functions as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs [, ]. DGCR8 binds heme, and this binding activates DGCR8 to recognize pri-miRs by specifically binding the terminal loop near the 3' single-stranded segment [].

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Allele

Gt(ROSA)26Sor<tm1.1(CAG-YFP/DROSHA*E1147K)Gess> | MGI:6887963

Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Manfred Gessler
Allele Type:	Targeted
Attribute String:	Conditional ready, Inserted expressed sequence, Reporter

•

GO Term

GO:0070877 | microprocessor complex

•

HT Experiment

GSE109075 | Transcriptome analyses of miRNA pathway mutants and injury response in developing and adult sciatic nerves


Experiment Type:	RNA-Seq
Study Type:	WT vs. Mutant
Source:	GEO

•

Publication

26748718 | -

First Author:	Kwon SC
Year:	2016
Journal:	Cell
Title:	Structure of Human DROSHA.
Volume:	164
Issue:	1-2
Pages:	81-90

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Genotype

Symbol:	Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Six2-EGFP/cre)1Amc/?
Background:	involves: 129S6/SvEvTac * C57BL/6 * CD-1
Zygosity:	cn
Has Mutant Allele:	true

•

HT Experiment

E-GEOD-20384 | Mammalian microRNAs: Experimental evaluation of novel and previously annotated genes

Series Id:	GSE20384
Experiment Type:	RNA-Seq
Study Type:	Baseline
Source:	ArrayExpress

•

Publication

17259983 | J:141670

First Author:	Wang Y
Year:	2007
Journal:	Nat Genet
Title:	DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal.
Volume:	39
Issue:	3
Pages:	380-5

•

Publication

36591274 | J:332443

First Author:	Daum P
Year:	2022
Journal:	Front Immunol
Title:	The microRNA processing subunit DGCR8 is required for a T cell-dependent germinal center response.
Volume:	13

Pages:	991347

•

Publication

26344767 | J:256665

First Author:	Tsujimura K
Year:	2015
Journal:	Cell Rep
Title:	miR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes.
Volume:	12
Issue:	11
Pages:	1887-901

•

Publication

34010654 | J:306623

First Author:	Nakashima H
Year:	2021
Journal:	Cell Rep
Title:	MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling.
Volume:	35
Issue:	7
Pages:	109124

•

Publication

25639470 | J:219960

First Author:	Ye P
Year:	2015
Journal:	Mol Cell
Title:	An mTORC1-Mdm2-Drosha axis for miRNA biogenesis in response to glucose- and amino acid-deprivation.
Volume:	57
Issue:	4
Pages:	708-20

•

Publication

24636259 | J:271380

First Author:	Cheng TL
Year:	2014
Journal:	Dev Cell
Title:	MeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8/Drosha complex.
Volume:	28
Issue:	5
Pages:	547-60

•

Publication

27641147 | J:246331

First Author:	Brandl A
Year:	2016
Journal:	Eur J Immunol
Title:	The microprocessor component, DGCR8, is essential for early B-cell development in mice.
Volume:	46
Issue:	12
Pages:	2710-2718

•

Publication

22910415 | J:188129

First Author:	Sohn EJ
Year:	2012
Journal:	Biochem Biophys Res Commun
Title:	Accumulation of pre-let-7g and downregulation of mature let-7g with the depletion of EWS.
Volume:	426
Issue:	1
Pages:	89-93

•

Publication

16882971 | J:111684

First Author:	Thomson JM
Year:	2006
Journal:	Genes Dev
Title:	Extensive post-transcriptional regulation of microRNAs and its implications for cancer.
Volume:	20
Issue:	16
Pages:	2202-7

•

Publication

19854141 | J:154163

First Author:	Yamagata K
Year:	2009
Journal:	Mol Cell
Title:	Maturation of microRNA is hormonally regulated by a nuclear receptor.
Volume:	36
Issue:	2
Pages:	340-7

•

Publication

23863840 | J:210405

First Author:	Mattioli C
Year:	2013
Journal:	Nucleic Acids Res
Title:	A competitive regulatory mechanism discriminates between juxtaposed splice sites and pri-miRNA structures.
Volume:	41
Issue:	18
Pages:	8680-91

•

Publication

26302406 | J:227348

First Author:	Kourtidis A
Year:	2015
Journal:	Nat Cell Biol
Title:	Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity.
Volume:	17
Issue:	9
Pages:	1145-57

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Protein

Q9EQM6

Organism:	Mus musculus/domesticus
Length:	773
Fragment?:	false

•

Protein Coding Gene

MGI:1916413 | Mrpl44

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Publication

18268334 | J:132169

First Author:	Du Z
Year:	2008
Journal:	Proc Natl Acad Sci U S A
Title:	Structural and biochemical insights into the dicing mechanism of mouse Dicer: a conserved lysine is critical for dsRNA cleavage.
Volume:	105
Issue:	7
Pages:	2391-6

•

Publication

26126715 | J:259443

First Author:	Tu CC
Year:	2015
Journal:	Sci Signal
Title:	The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage.
Volume:	8
Issue:	383
Pages:	ra64

•

Publication

28232627 | J:241293

First Author:	Marinaro F
Year:	2017
Journal:	EMBO Rep
Title:	MicroRNA-independent functions of DGCR8 are essential for neocortical development and TBR1 expression.
Volume:	18
Issue:	4
Pages:	603-618

•

Publication

29362439 | J:259678

First Author:	Zou Y
Year:	2018
Journal:	Sci Rep
Title:	Deletion of DGCR8 in VSMCs of adult mice results in loss of vascular reactivity, reduced blood pressure and neointima formation.
Volume:	8
Issue:	1
Pages:	1468

•

Publication

29760646 | J:264394

First Author:	Hoffmann N
Year:	2018
Journal:	Front Neurosci
Title:	DGCR8 Promotes Neural Progenitor Expansion and Represses Neurogenesis in the Mouse Embryonic Neocortex.
Volume:	12

Pages:	281

•

Publication

22511778 | J:186203

First Author:	Chen Z
Year:	2012
Journal:	J Biol Chem
Title:	DiGeorge syndrome critical region 8 (DGCR8) protein-mediated microRNA biogenesis is essential for vascular smooth muscle cell development in mice.
Volume:	287
Issue:	23
Pages:	19018-28

•

Publication

26833131 | J:251593

First Author:	Kim YS
Year:	2016
Journal:	Sci Rep
Title:	Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice.
Volume:	6

Pages:	20242

•

Publication

25944670 | J:249044

First Author:	Elgheznawy A
Year:	2015
Journal:	Circ Res
Title:	Dicer cleavage by calpain determines platelet microRNA levels and function in diabetes.
Volume:	117
Issue:	2
Pages:	157-65

•

Publication

17459947 | J:125844

First Author:	McCarthy JJ
Year:	2007
Journal:	Am J Physiol Cell Physiol
Title:	MicroRNA-206 is overexpressed in the diaphragm but not the hindlimb muscle of mdx mouse.
Volume:	293
Issue:	1
Pages:	C451-7

•

Publication

30985893 | J:277152

First Author:	Chen Y
Year:	2019
Journal:	Biol Reprod
Title:	CFTR mutation compromises spermatogenesis by enhancing miR-15b maturation and suppressing its regulatory target CDC25A†.
Volume:	101
Issue:	1
Pages:	50-62

•

Publication

22745822 | J:187930

First Author:	Messina V
Year:	2012
Journal:	PLoS One
Title:	The RNA binding protein SAM68 transiently localizes in the chromatoid body of male germ cells and influences expression of select microRNAs.
Volume:	7
Issue:	6
Pages:	e39729

•

Publication

35412895 | J:329928

First Author:	Hoang DH
Year:	2022
Journal:	Proc Natl Acad Sci U S A
Title:	MicroRNA networks in FLT3-ITD acute myeloid leukemia.
Volume:	119
Issue:	16
Pages:	e2112482119

•

Publication

19458619 | J:150365

First Author:	Trabucchi M
Year:	2009
Journal:	Nature
Title:	The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs.
Volume:	459
Issue:	7249
Pages:	1010-4

•

Publication

20413612 | J:160145

First Author:	Chiang HR
Year:	2010
Journal:	Genes Dev
Title:	Mammalian microRNAs: experimental evaluation of novel and previously annotated genes.
Volume:	24
Issue:	10
Pages:	992-1009

•

Publication

20624952 | J:162379

First Author:	Ling SC
Year:	2010
Journal:	Proc Natl Acad Sci U S A
Title:	ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.
Volume:	107
Issue:	30
Pages:	13318-23

•

Publication

22086916 | J:178957

First Author:	Dai L
Year:	2011
Journal:	J Biol Chem
Title:	Testis-specific miRNA-469 up-regulated in gonadotropin-regulated testicular RNA helicase (GRTH/DDX25)-null mice silences transition protein 2 and protamine 2 messages at sites within coding region: implications of its role in germ cell development.
Volume:	286
Issue:	52
Pages:	44306-18

•

Publication

23296057 | J:194285

First Author:	Rask L
Year:	2013
Journal:	Gene
Title:	Development of a metastatic fluorescent Lewis Lung carcinoma mouse model: identification of mRNAs and microRNAs involved in tumor invasion.
Volume:	517
Issue:	1
Pages:	72-81

•

Publication

22270084 | J:197722

First Author:	Havens MA
Year:	2012
Journal:	Nucleic Acids Res
Title:	Biogenesis of mammalian microRNAs by a non-canonical processing pathway.
Volume:	40
Issue:	10
Pages:	4626-40

•

Publication

22844086 | J:199666

First Author:	Dueck A
Year:	2012
Journal:	Nucleic Acids Res
Title:	microRNAs associated with the different human Argonaute proteins.
Volume:	40
Issue:	19
Pages:	9850-62

•

Publication

24334028 | J:223705

First Author:	Kim IM
Year:	2014
Journal:	Circ Res
Title:	β-arrestin1-biased β1-adrenergic receptor signaling regulates microRNA processing.
Volume:	114
Issue:	5
Pages:	833-44

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Publication

25057983 | J:224135

First Author:	Wang K
Year:	2014
Journal:	PLoS Genet
Title:	MDRL lncRNA regulates the processing of miR-484 primary transcript by targeting miR-361.
Volume:	10
Issue:	7
Pages:	e1004467

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Publication

25887159 | J:230535

First Author:	García R
Year:	2015
Journal:	Biochim Biophys Acta
Title:	p-SMAD2/3 and DICER promote pre-miR-21 processing during pressure overload-associated myocardial remodeling.
Volume:	1852
Issue:	7
Pages:	1520-30

•

Publication

26976605 | J:232041

First Author:	Kim YK
Year:	2016
Journal:	Proc Natl Acad Sci U S A
Title:	Re-evaluation of the roles of DROSHA, Export in 5, and DICER in microRNA biogenesis.
Volume:	113
Issue:	13
Pages:	E1881-9

•

Publication

21518849 | J:234608

First Author:	Ko JK
Year:	2011
Journal:	FASEB J
Title:	A versatile single-plasmid system for tissue-specific and inducible control of gene expression in transgenic mice.
Volume:	25
Issue:	8
Pages:	2638-49

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Publication

28486664 | J:245073

First Author:	Han X
Year:	2017
Journal:	Biol Reprod
Title:	MicroRNA-21 plays a pivotal role in the oocyte-secreted factor-induced suppression of cumulus cell apoptosis.
Volume:	96
Issue:	6
Pages:	1167-1180

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Protein Coding Gene

MGI:2151114 | Dgcr8

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Publication

25881298 | J:233486

First Author:	Bartram MP
Year:	2015
Journal:	BMC Nephrol
Title:	Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation.
Volume:	16

Pages:	55

•

Publication

26675618 | J:244796

First Author:	He M
Year:	2015
Journal:	PLoS One
Title:	GTPase Activating Protein (Sh3 Domain) Binding Protein 1 Regulates the Processing of MicroRNA-1 during Cardiac Hypertrophy.
Volume:	10
Issue:	12
Pages:	e0145112

•

Publication

29627294 | J:261785

First Author:	Teoh JP
Year:	2018
Journal:	J Mol Cell Cardiol
Title:	β-arrestin-biased agonism of β-adrenergic receptor regulates Dicer-mediated microRNA maturation to promote cardioprotective signaling.
Volume:	118

Pages:	225-236

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