| Primary Identifier | MGI:105093 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 12798 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable actin filament binding activity. Acts upstream of or within several processes, including negative regulation of macrophage migration; negative regulation of phagocytosis; and regulation of mononuclear cell proliferation. Predicted to be located in stress fiber. Predicted to be active in actin cytoskeleton. Is expressed in several structures, including 4-cell stage embryo; central nervous system; eye; forelimb; and lateral plate mesoderm. Orthologous to human CNN2 (calponin 2). PHENOTYPE: Mice homozygous for either a knock-out or a knock-down allele have reduced numbers of peripheral blood neutrophils and monocytes. Knock-out mice show increased macrophage proliferation, motility and phagocytosis, faster diapedesis of peripheral monocytesand neutrophils, and enhanced wound healing. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
