| Primary Identifier | MGI:88508 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 12928 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including ephrin receptor binding activity; signaling receptor complex adaptor activity; and ubiquitin protein ligase binding activity. Involved in several processes, including positive regulation of Rac protein signal transduction; positive regulation of skeletal muscle acetylcholine-gated channel clustering; and postsynaptic specialization assembly. Acts upstream of or within several processes, including activation of GTPase activity; nervous system development; and reelin-mediated signaling pathway. Located in actin cytoskeleton and membrane. Is active in neuromuscular junction. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; immune system; and musculature. Orthologous to human CRK (CRK proto-oncogene, adaptor protein). PHENOTYPE: Mice homozygous for an isoform specific knockout do not exhibit any obvious abnormalities. Mice homozygous of a null allele of both isoforms exhibit fetal and perinatal lethality associated with abnormal cardiovascular morphology. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
