Primary Identifier | MGI:99161 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 22658 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin binding activity. Acts upstream of or within several processes, including cellular response to hydrogen peroxide; chordate embryonic development; and negative regulation of transcription by RNA polymerase II. Located in nuclear body and sex chromatin. Part of PRC1 complex. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; eye; and genitourinary system. Orthologous to human PCGF2 (polycomb group ring finger 2). PHENOTYPE: Homozygous null mutants exhibit multiple abnormalities of the axial skeleton (including homeotic transformations), grow markedly slower, and die either perinatally or between 3-6 weeks of age depending on genetic background. [provided by MGI curators] |