Primary Identifier | MGI:1890393 | Organism | mouse, laboratory |
Chromosome | 12 | NCBI Gene Number | 246196 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cellular response to hydrogen peroxide and regulation of cellular senescence. Predicted to be located in chromosome; cytoplasm; and nucleolus. Is expressed in early conceptus and genitourinary system. Orthologous to human ZNF277 (zinc finger protein 277). PHENOTYPE: Mice homozygous for a knock-out allele exhibit early cellular preplicative senescence in MEFs. [provided by MGI curators] |