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Protein Coding Gene : Spin1 spindlin 1
Primary Identifier  MGI:109242 Organism  mouse, laboratory
Chromosome  13 NCBI Gene Number  20729
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables histone reader activity and methylated histone binding activity. Involved in protein localization to chromatin and transposable element silencing by piRNA-mediated DNA methylation. Located in spindle. Is active in chromatin. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human SPIN1 (spindlin 1).
PHENOTYPE: Mice homozygous for a gene trapped allele display complete postnatal lethality. Although mutant female mice exhibit normal follicular development and oocyte growth, fully grown oocytes are defective in resuming meiosis. [provided by MGI curators]
  • synonyms:
  • MGI:2142957,
  • MGD-MRK-38287,
  • expressed sequence AA673430,
  • spindlin 1,
  • AA673430,
  • MGI:2145170,
  • Spin1,
  • AA553322,
  • Spin,
  • spindlin,
  • expressed sequence AA553322
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