| Primary Identifier | MGI:95586 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 14313 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable activin binding activity; activin receptor antagonist activity; and heparan sulfate proteoglycan binding activity. Acts upstream of or within several processes, including BMP signaling pathway; hair follicle morphogenesis; and keratinocyte proliferation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; embryo mesenchyme; and genitourinary system. Used to study restrictive dermopathy. Human ortholog(s) of this gene implicated in polycystic ovary syndrome. Orthologous to human FST (follistatin). PHENOTYPE: Homozygous null mice show retarded growth, reduced diaphragm and intercostal muscle mass that lead to neonatal respiratory failure, shiny tight skin, defects of the hard palate and thirteenth ribs, and abnormal whiskers and teeth. Some conditional mutations produce female reproductive defects. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
