Primary Identifier | MGI:1353438 | Organism | mouse, laboratory |
Chromosome | 15 | NCBI Gene Number | 29857 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ATP binding activity; MAP kinase activity; and magnesium ion binding activity. Predicted to be involved in several processes, including myoblast differentiation; negative regulation of cell cycle; and peptidyl-serine phosphorylation. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in cap mesenchyme; cerebral cortex ventricular layer; lung mesenchyme; metanephros; and olfactory epithelium. Orthologous to human MAPK12 (mitogen-activated protein kinase 12). PHENOTYPE: Homozygous null mice are viable and fertile with no obvious abnormalities. Mice homozygous for a conditional allele activated in muscle cell exhibit decreased endurance exercise-induced mitochondrial biogenesis and angiogenesis. [provided by MGI curators] |