Primary Identifier | MGI:105060 | Organism | mouse, laboratory |
Chromosome | 16 | NCBI Gene Number | 110197 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ATP-dependent diacylglycerol kinase activity. Involved in several processes, including glycerolipid metabolic process; lipid phosphorylation; and negative regulation of phospholipase C/protein kinase C signal transduction. Predicted to be located in cytosol and membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; integumental system; and sensory organ. Orthologous to human DGKG (diacylglycerol kinase gamma). PHENOTYPE: Homozygous knockout leads to neurological deficits, including impaired motor coordination and reduced stride length, owing to Purkinje cell dysmorphology. [provided by MGI curators] |