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Protein Coding Gene : Bace2 beta-site APP-cleaving enzyme 2
Primary Identifier  MGI:1860440 Organism  mouse, laboratory
Chromosome  16 NCBI Gene Number  56175
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables peptidase activity. Involved in melanosome organization and signaling receptor ligand precursor processing. Located in plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE2 (beta-secretase 2).
PHENOTYPE: Homozygous mutation of this gene results in impaired APP processing by neurons and glia and coat color defects. [provided by MGI curators]
  • synonyms:
  • ALP56,
  • ARP1,
  • CDA13,
  • AI850424,
  • 1110059C24Rik,
  • beta-site APP-cleaving enzyme 2,
  • MGI:2146505,
  • RIKEN cDNA 1110059C24 gene,
  • MGI:1916053,
  • expressed sequence AI850424,
  • ASP21,
  • CEAP1,
  • BAE2,
  • Bace2
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