Primary Identifier | MGI:1931870 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 81630 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system gland; and liver. Orthologous to human ZBTB22 (zinc finger and BTB domain containing 22). PHENOTYPE: Mice homozygous for a null allele show protection from high-fat diet induced obesity, showing improved energy expenditure, glucose tolerance, and insulin sensitivity and reduced hepatic steatosis. [provided by MGI curators] |