| Primary Identifier | MGI:105382 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 16776 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables integrin binding activity. Involved in postsynapse organization. Acts upstream of or within several processes, including hair follicle development; morphogenesis of an epithelium; and trunk neural crest cell migration. Located in extracellular matrix. Part of laminin-10 complex. Is active in several cellular components, including collagen-containing extracellular matrix; glutamatergic synapse; and synaptic cleft. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; salivary gland primordium; and sensory organ. Used to study cystic kidney disease. Human ortholog(s) of this gene implicated in bent bone dysplasia syndrome 2 and familial nephrotic syndrome. Orthologous to human LAMA5 (laminin subunit alpha 5). PHENOTYPE: Homozygotes for a targeted null mutation exhibit disrupted basal laminae leading to exencephaly, syndactyly, placentopathy, kidney defects, abnormal lobar septation with absence of a visceral pleural membrane, and lethality in late gestation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
