| Primary Identifier | MGI:1096355 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 13609 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables sphingosine-1-phosphate receptor activity. Involved in several processes, including circulatory system development; lamellipodium assembly; and sphingosine-1-phosphate receptor signaling pathway. Acts upstream of or within several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; angiogenesis; and leukocyte chemotaxis. Located in external side of plasma membrane. Is active in presynapse. Is expressed in several structures, including brain; branchial arch; genitourinary system; heart; and limb. Orthologous to human S1PR1 (sphingosine-1-phosphate receptor 1). PHENOTYPE: Homozygotes for targeted mutations exhibit vascular defects resulting in embryonic hemorrhaging and lethality by embryonic day 14.5. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
