Primary Identifier | MGI:2180140 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 326623 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable cytokine activity and death receptor binding activity. Predicted to be involved in cell surface receptor signaling pathway; positive regulation of cytokine production; and positive regulation of signal transduction. Predicted to act upstream of or within positive regulation of cysteine-type endopeptidase activity. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Used to study inflammatory bowel disease 16. Orthologous to human TNFSF15 (TNF superfamily member 15). PHENOTYPE: Homozygous targeted mutants display decreased clinical severity in experimental autoimmune encephalomyelitis (EAE) and collagen-induced arthritis. [provided by MGI curators] |