Primary Identifier | MGI:109483 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 22644 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in ERAD pathway and protein ubiquitination. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in central nervous system; early conceptus; and genitourinary system. Orthologous to human RNF103 (ring finger protein 103). PHENOTYPE: Mice homozygous for a knock-out allele display significantly increased anxiety-like behavior under stressful conditions as well as increased prepulse inhibition and a reduced startle amplitude with no detectable changes in exploratory locomotion or behavioral despair. [provided by MGI curators] |