| Primary Identifier | MGI:1314884 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 21937 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables tumor necrosis factor receptor activity. Involved in several processes, including positive regulation of apoptotic process; regulation of lipid metabolic process; and semi-lunar valve development. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of transcription by RNA polymerase II; and regulation of tumor necrosis factor-mediated signaling pathway. Located in cell surface and membrane raft. Is active in plasma membrane. Is expressed in several structures, including extraembryonic component; genitourinary system; gut; hemolymphoid system; and nervous system. Used to study TNF receptorâassociated periodic syndrome. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; TNF receptorâassociated periodic syndrome; acne; allergic bronchopulmonary aspergillosis; and autoimmune disease (multiple). Orthologous to human TNFRSF1A (TNF receptor superfamily member 1A). PHENOTYPE: Homozygotes for targeted null mutations exhibit disrupted splenic architecture, increased adult liver weights, reduced IgG immune response, deficits in some host defense and inflammatory responses, LPS resistance, and reduced graft-vs-host disease. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
