| Primary Identifier | MGI:96764 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 16833 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables L-lactate dehydrogenase activity. Involved in pyruvate catabolic process. Acts upstream of or within ATP biosynthetic process; flagellated sperm motility; and lactate biosynthetic process from pyruvate. Located in cytoplasm and motile cilium. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human LDHC (lactate dehydrogenase C). PHENOTYPE: Homozygous male mice are infertile. Spermatogenesis appears normal, but sperm motility decreases rapidly after their release from the epididymus. In vitro fertilization is blocked unless the zona pellucida is removed; even then, the rate of sperm penetration is lower than for wild-type sperm. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
